Limitations of Current Anti-Diabetic Drugs
| Class | Mechanism | Disadvantage |
|---|---|---|
| Sulfonylureas | Insulin release | Weight gain, hypoglycemia |
| Metformin | Glucose production | Reduce appetite, hypoglycemia, GI side effects |
| TZD | Glucose usage | Weight gain, peripheral edema |
| AGI | Carbohydrate digestion | GI side effects |
| Meg | Insulin release | GI side effects |
| Insulin | Insulin | Weight gain, hypoglycemia |
| DPP4 inhibitor (Sitagliptin) | Insulin release, glucose production | Reduce appetite, hypoglycemia, GI side effects |
| GLP-1 agonist (Liraglutide) | Insulin release, glucose production | Reduce appetite, hypoglycemia, GI side effects |