miR-10b-5p Rescues Diabetes and Gastrointestinal Dysmotility

Rajan Singh, Se Eun Ha, Lai Wei, Byungchang Jin, Hannah Zogg, Sandra M. Poudrier, Brian G. Jorgensen, Chanjae Park, Charles F. Ronkon Allison Bartlett, Sung Cho, Addison Morales, Yu Heon Chung, Moon Young Lee, Jong Kun Park, Andres Gottfried-Blackmore, Linday Nguyen, Kenton M. Sanders, and Seungil Ro

Gastroenterology chart

Selected papers (IF: impact factor)

  1. Ro S, Park C, Young D, Sanders KM, and Yan W. Tissue-dependent paired expression of miRNAs. Nucleic Acids Research (IF: 19.16), 35(17):5944-53, 2007. PMID: 17726050
  2. Song R*, Ro S*, Michaels J, Park C, McCarrey JR, Yan W. Many X-linked microRNAs escape meiotic sex chromosome inactivation. Nature Genetics (IF: 38.330), 41(4):488-93, 2009 *Equally contributed. PMID: 19305411
  3. Ro S, Park C, Jin J, Zheng H, Blair PJ, Redelman D, Ward SM, Yan W, Sanders KM. A model to study the phenotypic changes of interstitial cells of Cajal (ICC) in gastrointestinal diseases. Gastroenterology (IF: 33.883), 138(3):1068-1078, PMID: 19917283
  4. ParkC, HennigGW, SandersKM, ChoJH, HattonW, RedelmanD, Park J, Ward SM, MianoJM, YanW, Ro S. Serum Response Factor-dependent microRNAs regulate gastrointestinal smooth muscle cell phenotypes. Gastroenterology (IF: 33.883), 141(1):164-175, PMID: 21473868
  5. Sanders KM, Koh SD, Ro S, Ward SM. Regulation of gastrointestinal motility – insights from smooth muscle biology. Nature Reviews Gastroenterology & Hepatology (IF: 73.082), 9(11):633-45, 2012. PMID: 22965426
  6. Ro S, Ma HY, Park C, Ortogero N, Song R, Hennig GW, Zheng H, Lin YM, Moro L, Hsieh JT, Yan W. The mitochondrial genome encodes abundant small noncoding RNAs. Cell Research (IF: 46.351), 23(6):759-74, 2013. PMID: 23478297
  7. Breland A*, Ha S*, Jorgensen BG*, Jin B, Gardner TA, Sanders KM, Ro S. Smooth Muscle Transcriptome Browser: offering genome-wide references of transcripts expressed in intestinal tissues and cells. Scientific Reports (IF: 4.011), 23;9(1):387, 2019 *Equally contributed. PMID: 30674925
  8. Singh R*, Ha S*, Wei L, Jin B, Zogg H, Poudrier SM, Jorgensen BG, Park C, Ronkon CF, Bartlett A, Cho S, Morales A, Chung Y, Lee MY, Park JK, Gottfried-Blackmore A, Nguyen L, Sanders KM, Ro S. miR-10b-5p rescues diabetes and gastrointestinal dysmotility. Gastroenterology (IF: 33.883), 160(5):1662-1678.e18, 2021 *Equally contributed. PMID: 33421511
  9. Ha S*, Jin B*, Clemmensen B, Park PJ, Mahboob S, Gladwill VA, Madhani-Lovely F, Gottfried A, Habtezion A, Verma SC, Ro S. Serotonin is elevated in COVID-19 associated diarrhea. Gut (IF: 31.795), 70(10):2015-2017, *Equally contributed PMID: 33402416
  10. Wei L, Singh R, Ha S, Martin AM, Jones L, Jin B, Jorgensen BG, Zogg H, Chervo T, Gottfried-Blackmore A, Nguyen L, Habtezion A, Spencer NJ, Keating DJ, Sanders KM, Ro S. Serotonin deficiency is associated with delayed gastric emptying. Gastroenterology (IF: 33.883), 160(7):2451-2466.e19, PMID: 33662386
  11. Jin B, Ha S, Wei L, Singh R, Zogg H, Clemmensen B, Heredia DJ, Gould TW, Sanders KM, Ro S. Colonic motility is improved by the activation of 5-HT2B receptors on interstitial cells of Cajal in diabetic mice. Gastroenterology (IF: 33.883), 161(2):608-622.e7, PMID: 33895170
  12. Jin B*, Singh R*, Ha S, Zogg H, Park PJ, Ro S. Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19. World Journal of Gastroenterology (IF: 5.374), 27(19):2341-2352, 2021. PMID: 34040326
  13. Singh R*, Zogg H*, Ro S. Role of microRNAs in disorders of gut-brain interactions: Clinical insights and therapeutic alternatives. Journal of Personalized Medicine (IF: 3.508), 11(10):1021, 2021 *Equally contributed. PMID: 34683162
  14. Singh R*, Zogg H*, Wei L*, Bartlett A, Ghoshal UC, Singh, R, Ro S. Gut microbial dysbiosis in the pathogenesis of gastrointestinal dysmotility and metabolic disorders. J Neurogastroenterol Motil (IF: 4.725), 27(1):19-34, 2021. PMID: 33166939
  15. Singh R*, Zogg H*, Ghoshal UC, Ro S. Current treatment options and therapeutic insights for gastrointestinal (GI) motility and functional GI disorders. Frontiers in Pharmacology (IF: 5.988), 13:808195, 2022 *Equally contributed. PMID: 35145413
  16. Zogg H*, Singh R*, Ro S. Current Advances in RNA Therapeutics for Human Diseases. International Journal of Molecular Sciences (IF: 6.208), 23(5):2736, 2022 *Equally contributed. PMID: 35269876
  17. Yunis H, Ha S, Jorgensen BG, Verma A, Ro S. Maturity Onset Diabetes of the Young: Mutations, Physiological Consequences, and Treatment Options. Journal of Personalized Medicine (IF: 3.508), 12(11):1762, 2022. PMID: 36573710

Department of Physiology and Cell Biology. School of Medicine, University of Nevada, Reno, Nevada; Division of Biological
Sciences, Wonkwang University, lksan, Chonbuk, Korea; Department of Physiology, Wonkwang Digestive Disease Research
Institute and Institute of Wonkwang Medical Science, School of Medicine. Wonkwang University, Iksan, Chonbuk, Korea; and
Division of Gastroenterology and Hepatology, Stanford University School of Medicine. Stanford, California

Scholarly Articles

Dr. Ro and Ro Lab's Research

**Impact Factor (IF) is referenced from the data in 2020 publicly acknowledged the best paper if IF>10 Source: National Center for Biotechnology Information (NCBI) research data results; (
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